Chica, who escaped from Peña's manhunt, returned to the red-light district and shot the prostitutes as revenge for them betraying him. After watching Colombian President Gaviria refuse to negotiate on TV, Escobar informed the president of his willingness to negotiate through an interview.
Meanwhile, U.S. President Bush, who focused on anti-terrorism, sent personnel to Colombia to take charge of the Escobar case and jointly bring him down. The tough Messina became Murphy and Peña's boss. Her first task was to deal with Murphy assaulting the Wall Street jerk, and Peña tried his best to speak well of Murphy in front of Messina, which saved the situation.
Messina warned Murphy not to cause trouble again, otherwise she would send him back to Miami. Escobar made no progress in finding Judy's laboratory and ordered his men to try their best to locate her. Escobar's interview led Chief Prosecutor Grieve to meet Duque, and Grieve told Duque that he was willing to make a deal with Escobar.
Upon learning of this, Vice President Edward went to argue with Grieve. Grieve told Edward that he was not the president's subordinate and that he had reason to suspect that Edward was at the cathedral on the day Escobar escaped from prison to help him flee. The two ended the conversation on bad terms. Colonel Pizano surrounded Medellín and set up a hotline for reporting Escobar for a whole day, but got no practically useful clues.
Chica, who had killed all the prostitutes, insisted that none should be spared and wanted to shoot Marisa. Limón couldn't bear it and helped Marisa escape Chica's pursuit. Fernando persuaded Escobar to try giving up negotiating with the president and instead make a deal with Chief Prosecutor Grieve. Escobar's wife Tata said she wanted to leave Colombia, as she couldn't stand living a life on the run anymore.
On the U.S. DEA side, after learning the clue that Chica collected toilets, they searched for the calls of Escobar's hitman Velasco through the Intelligence Support Activity and locked down Escobar's residence. Messina went to Colonel Pizano to request support but was refused. In the end, Messina got Pizano to have to provide support through Crosby, but Pizano politely refused to sneak in and surround Escobar, choosing instead to do it with great fanfare. As a result, the attempt to arrest Escobar failed.
After hiding from the police all night, Tata expressed her worries to Escobar again, and Escobar comforted her. Escobar, who had endured the presence of Colonel Pizano's policemen all over Medellín in his efforts to negotiate, decided to declare war on the government after fleeing for half the night and launched a terrorist attack on the police. In this terrorist attack, Limón shot and killed someone for the first time, and the police suffered heavy casualties.