Escobar continued his terrorist activities. After placing 220 pounds of explosives in a Bogotá shopping mall, causing heavy casualties and damage, he completely angered the public—no one supported him anymore.
Attorney General Grieve offered to send Escobar's family out of Colombia on the condition that he stop the violence and surrender to the government. Learning through the media that Escobar was about to fall, the Cali Cartel traveled to Miami to take over the markets previously controlled by Escobar.
Tata, detained under the guise of protection, could not contact Escobar. She discussed what to do with Escobar's mother, Hermilda. As Escobar's organization collapsed, the time to capture him had come, and Colonel Martínez voiced his opinions.
With events spiraling out of control, Peña told Murphy to prepare an escape route for himself. Blakey, who was monitoring the safety of Escobar's family, out of kindness, informed Escobar that his family was safe—even though he had not seen them.
Shortly after, Blakey was arrested. Meanwhile, Judy went to persuade the Gaon Gang to join them. The Gaon Gang agreed, but one of their henchmen informed Chica of the deal. Escobar decided to confront the Gaon Gang at the Monti Casino for a final showdown.
At the same time, although Peña and Murphy did not get Escobar's location from interrogating Blakey, they obtained information about Chica. On the other hand, Baco's trip to Miami to take over the markets went smoothly because he had bribed El León. After fully seizing control of the Miami markets, El León was killed.
Tata turned to Valeria for help. Valeria brought Tata a walkie-talkie and cash entrusted by Escobar, and Tata finally made contact with Escobar. With Blakey betraying Chica, the search team formulated a series of plans to arrest Chica.
Meanwhile, Attorney General Grieve asked the president to resettle Escobar's family, but the president refused. News that Valeria had been killed by the "People Persecuted by Pablo Escobar" (Los Pepes) and that Miami had fallen arrived simultaneously. Enraged, Escobar declared an official war against their alliance.
Chica and Ricardo took accountant Rojas to collect money. Along the way, Chica was constantly tracked by Peña via phone calls. Realizing something was wrong, Chica killed Ricardo and Rojas, planning to flee with the money alone—but he was successfully surrounded and arrested by the search team.
Chica, Escobar's most trusted lieutenant, was arrested. Wanting to start a new life, Chica agreed to cooperate with the police after Peña and Murphy promised to help him rebuild his life. In the end, Chica agreed to work with the police and revealed the organization's meeting times and locations.
On the other side, Escobar and Limón had already set off. On the way, they received a call from Chica, who was instructed by the police. Realizing it was a trap, Escobar called Tata to inform her that he could not contact her in the near future and refused to talk about anything else. After the call, Escobar told Limón to take another route, lying that Chica and the others had left. The ambushing police missed the chance to capture Escobar once again.